DECURSINOL-50®
Product Overview
Decursinol-50®, a proprietary blend of natural phytochemicals, is clinically proven to reduce joint pain, promote joint health, and improve flexibility and mobility. Clinical studies have shown that Decursinol-50® acts quickly to reduce the inflammation pain associated with arthritis, in addition to any acute pain.
Decursinol-50® is an extract of the root of Angelica gigas Nakai (Korean Angelica), which is an excellent source of pain-relief agents decursin and decursinol.
Developed for oral consumption, Decursinol-50® works synergistically with Glucosamine, Chondroitin, MSM, SAMe, and other osteoarthritis medications, including Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as aspirin, naproxen, and ibuprofen.
Human Clinical Study Results
Results revealed:
- VAS score improved up to 70%
- Significant pain reduction in both arthritis and trauma pain groups (changes of 13% have clinical significance)
- Statistically significant (p<0.001)
- No adverse effects
Single-Dose Animal Toxicology Study
From the study results, we have estimated that the LD50 of Decursinol-50® in rats is 3,722 mg/Kg for males and 2,804 mg/Kg for females.
Repeat-Dose Animal Toxicology Study
Investigations of 4-week repeat-dose toxicity of Decursinol-50® in SD rats did not find any significant toxicological changes in the high dose group (500mg/Kg), though it did find a 10% loss of body weight compared to the control group. The maximum tolerable dose of the test material is therefore below 500 mg/Kg, while the non-toxic dose level is above 100 mg/Kg. From these results, Decursinol-50® is considered to be highly appropriate for human use.
- All animals survived the test period
- No clinical abnormalities were found across all dose level and all animals
- No abnormalities were observed across all test groups, including the control group
- No abnormalities were observed in the urine analyses across all test groups, including the control group
- No abnormalities were observed in the necropsy gross findings across all test groups, including the control group